Open AccessThe in vivo activity of olamufloxacin (HSR-903) in systemic and urinary tract infections in mice
Author(s) -
Satoshi Yoshizumi
Publication year - 2001
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/48.1.137
Subject(s) - sparfloxacin , ciprofloxacin , in vivo , urinary system , levofloxacin , pseudomonas aeruginosa , microbiology and biotechnology , medicine , antibiotics , pharmacology , bacteria , biology , ofloxacin , genetics
The in vivo activity of olamufloxacin (HSR-903), a new fluoroquinolone, was evaluated and compared with ciprofloxacin, sparfloxacin and levofloxacin. Olamufloxacin was active against systemic infection in mice inoculated with both Gram-positive and -negative bacteria. Olamufloxacin had equal efficacy for experimental urinary tract infections in mice caused by Pseudomonas aeruginosa.
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