The effect of amiloride on amphotericin B-induced hypokalaemia | Zendy

David T. Bearden | Zendy; L A Muncey | Zendy

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The effect of amiloride on amphotericin B-induced hypokalaemia

Author(s) -

David T. Bearden,

L A Muncey

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/48.1.109

Subject(s) - amiloride , hypokalemia , potassium , medicine , amphotericin b , wasting , endocrinology , gastroenterology , sodium , pharmacology , chemistry , antifungal , organic chemistry , dermatology

Amiloride was administered to 19 oncology patients exhibiting marked amphotericin B-induced electrolyte wasting. Mean serum potassium concentrations increased in the 5 days preceding and following administration (3.4 +/- 0.5 versus 3.9 +/- 0.8 mmol/L, P = 0.002). A trend towards decreased potassium supplementation was also observed (48.0 +/- 66.5 versus 29.4 +/- 43.2 mmol/day, P = 0.12). Amiloride is a therapeutic option to decrease potassium wasting in patients being treated with amphotericin B.

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