The effect of Escherichia coli heat-stable toxin on the trans-epithelial intestinal elimination of ciprofloxacin in the rabbit | Zendy

A Musafija | Zendy; Y. Shtelman | Zendy; J. Ramon | Zendy; Marko Volk | Zendy; Shlomo Segev | Zendy; Eric Rubinstein | Zendy

Open Access

The effect of Escherichia coli heat-stable toxin on the trans-epithelial intestinal elimination of ciprofloxacin in the rabbit

Author(s) -

A Musafija,

Y. Shtelman,

J. Ramon,

Marko Volk,

Shlomo Segev,

Eric Rubinstein

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/47.5.697

Subject(s) - ciprofloxacin , escherichia coli , toxin , microbiology and biotechnology , intestinal epithelium , biology , epithelium , chemistry , antibiotics , biochemistry , genetics , gene

The effect of Escherichia coli heat-stable toxin (ST) on the intestinal trans-epithelial elimination of ciprofloxacin was studied in the rabbit model. Following a systemic 27 mg/kg dose, excreted amounts of ciprofloxacin during the 2 h experiment were: 9.3 (+/- 4.8); 12.5 (+/- 5.2) and 0.3 (+/- 0.1) microg/cm(2) surface of intestinal wall in ST-challenged jejunal, ileal and caecal loops, respectively. In control loops the corresponding amounts were: 5.0 (+/- 2.8), 6.5 (+/- 3.4) and 0.3 (+/- 0.1) microg/cm(2), respectively. The trans-epithelial elimination of ciprofloxacin was significantly higher in ST-challenged small bowel loops than in controls while caecal elimination was negligible.

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