The relationship between trends in macrolide use and resistance to macrolides of common respiratory pathogens | Zendy

Milan Čižman | Zendy; Marko Pokorn | Zendy; Katja Seme | Zendy; Andreja Oražem | Zendy; Metka Paragi | Zendy

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The relationship between trends in macrolide use and resistance to macrolides of common respiratory pathogens

Author(s) -

Milan Čižman,

Marko Pokorn,

Katja Seme,

Andreja Oražem,

Metka Paragi

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/47.4.475

Subject(s) - streptococcus pneumoniae , moraxella catarrhalis , haemophilus influenzae , microbiology and biotechnology , streptococcus pyogenes , moraxella (branhamella) catarrhalis , macrolide antibiotics , ketolide , moraxella , biology , medicine , erythromycin , antibiotics , bacteria , staphylococcus aureus , genetics

The correlation between increased macrolide consumption and the resistance of Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to macrolides in Slovenia from 1994 to 1999 was evaluated. The outpatient consumption of macrolides increased from 1.89 to 3.84 defined daily doses (DDD)/1000 inhabitants/day during the observation period. This increase in macrolide consumption was paralleled by a steady increase in macrolide resistance in S. pyogenes (from 0 to 7.4%, r = 0.90, P = 0.014) and upper respiratory S. pneumoniae isolates (from 0 to 9%, r = 0.82, P = 0.044). In other pathogens studied, no significant increase was detected.

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