Phenotypic and genotypic characterization of macrolide-resistant group A Streptococcus strains in the province of Quebec, Canada | Zendy

Karl Heinz Weiss | Zendy; Joyce de Azavedo | Zendy; C Restieri | Zendy; Lise-Andrée Galarneau | Zendy; Marie Gourdeau | Zendy; P. Harvey | Zendy; Jean Paradis | Zendy; Kamariah Abu Salim | Zendy; Donald E. Low | Zendy

Open Access

Phenotypic and genotypic characterization of macrolide-resistant group A Streptococcus strains in the province of Quebec, Canada

Author(s) -

Karl Heinz Weiss,

Joyce de Azavedo,

C Restieri,

Lise-Andrée Galarneau,

Marie Gourdeau,

P. Harvey,

Jean Paradis,

Kamariah Abu Salim,

Donald E. Low

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/47.3.345

Subject(s) - erythromycin , serotype , microbiology and biotechnology , clindamycin , biology , genotype , streptococcus pneumoniae , streptococcus pyogenes , streptococcaceae , clone (java method) , pulsed field gel electrophoresis , population , streptococcus , gene , antibiotics , genetics , bacteria , staphylococcus aureus , medicine , environmental health

Resistance to macrolides among group A streptococci is an increasing problem worldwide. We examined 496 strains phenotypically and genotypically for resistance to erythromycin and clindamycin. Strains were isolated in five different geographical areas representing about 45% of the total Quebec population. The overall resistance rate was 4.6% but varied from 0% in rural areas to 9.4% in Montreal. Of the 23 strains showing resistance to erythromycin, 15 (65%) had an identical pulsed-field gel electrophoresis pattern, were of serotype M28T28 and harboured the erm(TR) gene, suggesting the spread of a single clone. Of the remaining eight strains, two strains had the erm(B) gene, five had the mef gene and one with a different serotype also had the erm(TR) gene.

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