Single-dose pharmacokinetics of levofloxacin during continuous veno-venous haemofiltration in critically ill patients | Zendy

Friederike Traunmüller | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Single-dose pharmacokinetics of levofloxacin during continuous veno-venous haemofiltration in critically ill patients

Author(s) -

Friederike Traunmüller

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/47.2.229

Subject(s) - levofloxacin , pharmacokinetics , medicine , critically ill , hemofiltration , anesthesia , pharmacology , intensive care medicine , surgery , hemodialysis , antibiotics , chemistry , biochemistry

The present study was performed to analyse the pharmacokinetics of levofloxacin during continuous veno-venous haemofiltration (CVVH) with a high-flux polyamide membrane. Twelve patients received 500 mg levofloxacin intravenously. The mean levofloxacin concentration peak was 1.9 +/- 1.0 mg/L. The elimination half-life, haemofiltration clearance and total removal were 8.3 +/- 2.6 h, 27.6 +/- 8.4 mL/min and 56 +/- 19%, respectively. Further multiple-dose studies are required to enable dosage recommendations to be made for patients receiving renal replacement therapy with CVVH.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research