Individual use of antibiotics and prevalence of beta-lactamase production among bacterial pathogens from middle ear fluid | Zendy

Nana Thrane | Zendy

Open Access

Individual use of antibiotics and prevalence of beta-lactamase production among bacterial pathogens from middle ear fluid

Author(s) -

Nana Thrane

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/47.2.211

Subject(s) - moraxella catarrhalis , antibiotics , haemophilus influenzae , medicine , moraxella (branhamella) catarrhalis , confidence interval , microbiology and biotechnology , moraxella , clavulanic acid , bacteria , biology , amoxicillin , genetics

Prescription data and clinical laboratory data were analysed to assess the influence of previous antibiotic therapy on the prevalence of beta-lactamase in isolates of Haemophilus influenzae and Moraxella catarrhalis from primary specimens of middle ear fluid from 2129 children aged 0-5 years. The prevalence of beta-lactamase-positive H. influenzae was 6.6% [95% confidence interval (CI): 3.5-9.8%] in children who received antibiotics 5-90 days before isolation of the organism compared with 7.0% (95% CI: 3.9-10.2%) in those who did not. The prevalence of beta-lactamase-positive M. catarrhalis was 90.9% (95% CI: 84.0-97.8%) in children who received antibiotics compared with 86.7% (95% CI: 79.0-94.4%) in those who did not.

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