High rates of resistance to cephalosporins among viridans-group streptococci causing bacteraemia in neutropenic cancer patients | Zendy

A. Marrón | Zendy; Jordi Carratalà | Zendy; Fernando Alcaide | Zendy; A. FernándezSevilla | Zendy; Francesc Gudiol | Zendy

Open Access

High rates of resistance to cephalosporins among viridans-group streptococci causing bacteraemia in neutropenic cancer patients

Author(s) -

A. Marrón,

Jordi Carratalà,

Fernando Alcaide,

A. FernándezSevilla,

Francesc Gudiol

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/47.1.87

Subject(s) - cephalosporin , medicine , bacteremia , viridans streptococci , neutropenia , microbiology and biotechnology , cancer , antibiotics , streptococcus , biology , bacteria , chemotherapy , genetics

The prevalence of resistance to cephalosporins among viridans-group streptococci causing 88 (18%) cases among 485 bacteraemias in neutropenic cancer patients was studied. Rates of resistance to ceftriaxone, ceftazidime, cefpirome and cefepime were 22, 53, 14 and 34%, respectively. Previous administration of beta-lactam therapy was the only factor significantly associated with bacteraemia due to cephalosporin-resistant strains; only 11 (16%) of 68 patients infected with cephalosporin-susceptible bacteria had received these antibiotics compared with 10 (50%) of 20 patients infected with cephalosporin-resistant bacteria (P = 0.0052).

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