In vitro activity of linezolid against multiply resistant Gram-positive clinical isolates
Author(s) -
Emilia Cercenado
Publication year - 2001
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/47.1.77
Subject(s) - teicoplanin , linezolid , microbiology and biotechnology , vancomycin , penicillin , antibiotics , glycopeptide , erythromycin , in vitro , biology , staphylococcus aureus , bacteria , biochemistry , genetics
The in vitro activity of the oxazolidinone linezolid was compared with the activities of vancomycin and teicoplanin against 450 Gram-positive clinical isolates, including a variety of multiply resistant strains. Linezolid inhibited all microorganisms tested at < or = 4 mg/L, including methicillin- and teicoplanin-resistant staphylococci, glycopeptide-resistant enterococci, penicillin- and multiply resistant pneumococci and viridans streptococci, and erythromycin-resistant beta-haemolytic streptococci. The MIC(90) of linezolid for all isolates was 2 mg/L.
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