Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model | Zendy

P. Cottagnoud | Zendy; C. M. Gerber | Zendy; F. Acosta | Zendy; M. Cottagnoud | Zendy; K Neftel | Zendy; Martin G. Täuber | Zendy

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Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model

Author(s) -

P. Cottagnoud,

C. M. Gerber,

F. Acosta,

M. Cottagnoud,

K Neftel,

Martin G. Täuber

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/46.6.981

Subject(s) - linezolid , ceftriaxone , penicillin , microbiology and biotechnology , vancomycin , antibiotics , medicine , streptococcus pneumoniae , meningitis , staphylococcus aureus , pharmacology , biology , bacteria , surgery , genetics

Linezolid, a new oxazolidinone antibiotic, showed good penetration (38+/-4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two i.v. injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally bactericidal at concentrations above the MIC (5 x and 10 x MIC).

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