Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG | Zendy

B. Murugasu-Oei | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG

Author(s) -

B. Murugasu-Oei

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/46.6.917

Subject(s) - nitrofurazone , bacilli , microbiology and biotechnology , mycobacterium bovis , nitrofuran , metronidazole , nitroimidazole , bacillus (shape) , bacteria , antibiotics , biology , mycobacterium tuberculosis , chemistry , tuberculosis , medicine , traditional medicine , genetics , organic chemistry , pathology

Depletion of oxygen triggers the shift-down of Mycobacterium bovis BCG to a state of dormancy. Bacilli in their dormant state are resistant to standard anti-mycobacterials. The nitroimidazole metronidazole was the first compound identified to show bactericidal activity against dormant tubercle bacilli. In contrast to metronidazole's selective toxicity for dormant bacilli, we report here that the nitrofurans nitrofurantoin, furaltadone and nitrofurazone showed bactericidal activity against dormant and growing bacteria. Importantly, the bactericidal effect of nitrofurans on dormant bacilli was 35- to 250-fold higher compared with metronidazole.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research