A novel method for collecting and detecting amoxycillin in urine: a tool for testing antibiotic compliance in the community | Zendy

Wei Shen Lim | Zendy

Open Access

A novel method for collecting and detecting amoxycillin in urine: a tool for testing antibiotic compliance in the community

Author(s) -

Wei Shen Lim

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/46.5.835

Subject(s) - urine , antibiotics , medicine , amoxicillin , urinary system , antibacterial agent , microbiology and biotechnology , biology

Assessing compliance to prescribed antibiotics in community studies of respiratory tract infections is difficult. We describe a simple method for collecting and detecting amoxycillin in urine using urine dip-sticks in conjunction with a bioassay. Urine was collected at timed intervals from eight healthy volunteers following oral amoxycillin administration. Dip-sticks inoculated with urine collected 1 and 8 h after antibiotic resulted in mean zones of inhibition of 1.75 and 1.37 cm, respectively. Amoxycillin activity remained demonstrable 14 days after inoculation of dip-sticks with urine. Dip-sticks inoculated with urine from control subjects who had not taken amoxycillin did not cause inhibition.

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