In vivo activity of levofloxacin alone or in combination with imipenem or amikacin in a mouse model of Acinetobacter baumannii pneumonia | Zendy

MarieLaure JolyGuillou | Zendy; Michel Wolff | Zendy; Robert Farinotti | Zendy; A. Bryskier | Zendy; C Carbon | Zendy

Open Access

In vivo activity of levofloxacin alone or in combination with imipenem or amikacin in a mouse model of Acinetobacter baumannii pneumonia

Author(s) -

MarieLaure JolyGuillou,

Michel Wolff,

Robert Farinotti,

A. Bryskier,

C Carbon

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/46.5.827

Subject(s) - levofloxacin , acinetobacter baumannii , amikacin , imipenem , microbiology and biotechnology , in vivo , pneumonia , medicine , acinetobacter , antibiotics , pharmacology , antibiotic resistance , biology , pseudomonas aeruginosa , bacteria , genetics

We evaluated the in vivo activity of levofloxacin alone or in combination with imipenem or amikacin in a mouse model of Acinetobacter baumannii pneumonia using a susceptible strain and one with low-level resistance (MIC/MBC of levofloxacin: 0.06/0.06 and 4/4 mg/L, respectively). As demonstrated previously with other pathogens, the AUC/MIC ratio predicted the efficacy of fluoroquinolones against A. baumannii. This parameter correlated with bactericidal effect and survival. Combination therapy did not enhance the efficacy of levofloxacin.

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