Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France | Zendy

Véronique Lemee | Zendy

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Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France

Author(s) -

Véronique Lemee

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/46.5.819

Subject(s) - metronidazole , albendazole , giardia , microbiology and biotechnology , giardia lamblia , drug resistance , biology , medicine , antibiotics , gastroenterology , surgery

The metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France was determined using a neonatal mouse model and compared with the outcome in patients after standard metronidazole therapy (0.75 g/day for 5 days). All isolates found to be clinically resistant to metronidazole (4/11) exhibited an ID50 > 120 mg/kg in the mouse model. This therefore appears to be a suitable animal model in which to explore drug failures in human giardiasis.

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