Plasma, urine and skin pharmacokinetics of cefepime in burns patients | Zendy

Emmanuelle Sampol | Zendy

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Plasma, urine and skin pharmacokinetics of cefepime in burns patients

Author(s) -

Emmanuelle Sampol

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/46.2.315

Subject(s) - cefepime , pharmacokinetics , urine , medicine , penetration (warfare) , pharmacology , anesthesia , antibiotics , chemistry , biochemistry , antibiotic resistance , imipenem , operations research , engineering

We studied the pharmacokinetics of cefepime (2 g bd) in six burns patients. Blood, urine and skin samples were collected to measure cefepime concentrations. A two-compartment model was fitted to the data. At day 1, t(1/2beta) was 2.45 +/- 0.56 h, V(ss) 0.36 +/- 0.1 L/kg, total clearance 152 +/- 25.2 mL/min, and AUC 217 +/- 34 mg*h/L. There was no statistical difference between day 1 and day 3 for any of the pharmacokinetic parameters. We demonstrated good penetration of cefepime in skin. These results show that it is not necessary to change the standard dosage of cefepime in burns patients.

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