Salicylate induction of phenotypic resistance to quinolones in Serratia marcescens | Zendy

Mercedes Berlanga | Zendy

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Salicylate induction of phenotypic resistance to quinolones in Serratia marcescens

Author(s) -

Mercedes Berlanga

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/46.2.279

Subject(s) - nalidixic acid , serratia marcescens , salicylic acid , ciprofloxacin , microbiology and biotechnology , bacterial outer membrane , porin , membrane permeability , chemistry , bacteria , serratia , lipopolysaccharide , antibiotics , biology , biochemistry , escherichia coli , membrane , pseudomonas , genetics , gene , endocrinology

The influence of salicylic acid on the permeability and susceptibility of Serratia marcescens to both nalidixic acid and ciprofloxacin was studied, as well as the effect of salicylate on outer membrane proteins and lipopolysaccharide. As salicylic acid concentration increased, ciprofloxacin accumulation decreased with a concomitant, previously observed, reduction in the porin content of the outer membrane. Resistance to ciprofloxacin and nalidixic acid was enhanced when bacteria grew in the presence of salicylic acid.

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