In vitro activity of telithromycin (HMR 3647) and seven other antimicrobial agents against anaerobic bacteria | Zendy

G Ackermann | Zendy; Reiner Schaumann | Zendy; B. Pless | Zendy; Marina C. Claros | Zendy; Arne C. Rodloff | Zendy

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In vitro activity of telithromycin (HMR 3647) and seven other antimicrobial agents against anaerobic bacteria

Author(s) -

G Ackermann,

Reiner Schaumann,

B. Pless,

Marina C. Claros,

Arne C. Rodloff

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/46.1.115

Subject(s) - telithromycin , antimicrobial , microbiology and biotechnology , bacteria , antibacterial agent , anaerobic bacteria , antibiotics , biology , in vitro , ketolide , anaerobic exercise , biochemistry , genetics , physiology

We assessed the in vitro activity of telithromycin (HMR 3647) and seven other antimicrobials against 292 strains of obligately anaerobic bacteria. MICs were determined with the microdilution technique and Wilkins-Chalgren broth according to DIN 58940-83. MIC50/MIC90s (mg/L) for telithromycin were 4/4 for Bacteroides fragilis, Bacteroides ovatus and Bacteroides thetaiotaomicron, 2/4 for Fusobacterium spp. and Bilophila wadsworthia, 2/2 for Bacteroides caccae, 1/4 for Bacteroides vulgatus, 0.25/4 for Prevotella spp., > or =0.03/0.5 for Clostridium spp. and 0.125/4 for Peptostreptococcus spp.

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