Presence of ROB-1 -lactamase correlates with cefaclor resistance among recent isolates of Haemophilus influenzae | Zendy

James A. Karlowsky | Zendy; Geetika Verma | Zendy; George G. Zhanel | Zendy; D. J. Hoban | Zendy

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Presence of ROB-1 -lactamase correlates with cefaclor resistance among recent isolates of Haemophilus influenzae

Author(s) -

James A. Karlowsky,

Geetika Verma,

George G. Zhanel,

D. J. Hoban

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/45.6.871

Subject(s) - cefaclor , haemophilus influenzae , cefuroxime , cefotaxime , microbiology and biotechnology , cefixime , cephalosporin , haemophilus , medicine , biology , antibiotics , bacteria , genetics

beta-Lactamase production in Canadian isolates of Haemophilus influenzae has remained relatively constant (25-35%) over the last decade despite increasing cefaclor resistance (MIC >/= 32 mg/L). TEM (294/324, 90.7%) and ROB-1 (30/324, 9.3%) prevalence rates among 324 isolates of H. influenzae obtained from across Canada in 1997-1998 were similar (P > 0.05) to previously published reports. However, 66. 7% (26/39) of cefaclor-resistant isolates were ROB-1-positive (P < 0. 001) and the remaining four ROB-1-positive isolates were cefaclor-intermediate (MIC 16 mg/L). Susceptibilities to loracarbef (P < 0.001) and cefprozil were also reduced in the presence of ROB-1 while the activities of cefuroxime, cefotaxime, cefixime and imipenem were similar in both TEM- and ROB-1-positive solates.

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