Antibiotic resistance in respiratory tract isolates of Haemophilus influenzae and Moraxella catarrhalis collected from across Canada in 1997-1998 | Zendy

George G. Zhanel | Zendy

Open Access

Antibiotic resistance in respiratory tract isolates of Haemophilus influenzae and Moraxella catarrhalis collected from across Canada in 1997-1998

Author(s) -

George G. Zhanel

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/45.5.655

Subject(s) - moraxella catarrhalis , microbiology and biotechnology , haemophilus influenzae , ampicillin , cefotaxime , moraxella (branhamella) catarrhalis , cefixime , amp resistance , moraxella , streptococcus pneumoniae , ciprofloxacin , levofloxacin , medicine , trimethoprim , antibiotics , biology , cephalosporin , bacteria , genetics

Between September 1997 and November 1998 respiratory tract isolates of Haemophilus influenzae (n = 1352) and Moraxella catarrhalis (n = 428) were collected by 18 Canadian medical centres. beta-Lactamase was produced by 24.0 and 94.2% of H. influenzae and M. catarrhalis isolates, respectively. Resistance rates for H. influenzae were highest for ampicillin (24.0%), trimethoprim/sulphamethoxazole (13. 7%), loracarbef (6.1%) and cefaclor (4.2%), and </= 1% for amoxycillin/clavulanate, cefotaxime, cefprozil, cefixime, imipenem, ciprofloxacin, levofloxacin, grepafloxacin, trovafloxacin and chloramphenicol. M. catarrhalis resistance rates, derived using NCCLS breakpoint criteria for Haemophilus spp., were </= 1% for all antibiotics tested except ampicillin (49.5%) and trimethoprim/sulphamethoxazole (1.6%).

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