Comparative therapeutic efficacy of clinafloxacin in a pneumococcal meningitis mouse model | Zendy

Martin A. Shapiro | Zendy; K. D. Donovan | Zendy; Jeffrey W. Gage | Zendy

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Comparative therapeutic efficacy of clinafloxacin in a pneumococcal meningitis mouse model

Author(s) -

Martin A. Shapiro,

K. D. Donovan,

Jeffrey W. Gage

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/45.4.489

Subject(s) - ceftriaxone , streptococcus pneumoniae , penicillin , meningitis , microbiology and biotechnology , ciprofloxacin , medicine , pneumococcal infections , antibiotics , potency , pharmacology , biology , surgery , in vitro , biochemistry

The therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, was compared with that of ciprofloxacin and ceftriaxone in a novel pneumococcal meningitis mouse model. Mice were challenged by the intracerebral ventricular route with 50 IL of a lethal bacterial suspension and treated subcutaneously 2 h later. Both penicillin-susceptible and multidrug-resistant pneumococcal strains were used for evaluation. Survival percentages were calculated as the median curative dose (CD50) using log-probit statistical methods. Ceftriaxone was the most active agent against the penicillin-susceptible strain (CD50 = 2 mg/kg), but showed a 30-fold decrease in potency against the resistant strain. Clinafloxacin was equally effective against both strains, and proved to be the most active agent against the penicillin-resistant pneumococcus.

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