Anticandidal activity of SPA-S-843, a new polyenic drug | Zendy

V. Strippoli | Zendy; Felicia Diodata D’Auria | Zendy; Giovanna Simonetti | Zendy; T. Bruzzese | Zendy; N Simonetti | Zendy

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Anticandidal activity of SPA-S-843, a new polyenic drug

Author(s) -

V. Strippoli,

Felicia Diodata D’Auria,

Giovanna Simonetti,

T. Bruzzese,

N Simonetti

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/45.2.235

Subject(s) - candida albicans , polyene , antimicrobial , microbiology and biotechnology , yeast , chemistry , amphotericin b , drug , biological activity , antifungal , biology , in vitro , biochemistry , pharmacology

The activity of a new, soluble and stable polyene (SPA-S-843) against Candida albicans was assessed by contact and culture tests and by inhibition of germ-tube formation. The drug demonstrated a higher contact activity and lower MICs than amphotericin B. This antimicrobial activity was more evident under acid pH and low ionic strength. In addition, the ability of SPA-S-843 to inhibit Candida sp. conversion from yeast to mycelial form was evident at low drug concentrations (0.25-0.62 mg/L).

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