Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid | Zendy

Keith M. Olsen | Zendy; Tom E. Peddicord | Zendy; G. Douglas Campbell | Zendy; Mark E. Rupp | Zendy

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Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid

Author(s) -

Keith M. Olsen,

Tom E. Peddicord,

G. Douglas Campbell,

Mark E. Rupp

Publication year - 2000

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/45.2.217

Subject(s) - bronchoalveolar lavage , lidocaine , streptococcus pneumoniae , saline , moraxella catarrhalis , haemophilus influenzae , microbiology and biotechnology , candida albicans , medicine , antimicrobial , anesthesia , biology , antibiotics , lung

The antimicrobial activity of lidocaine in bronchoalveolar lavage fluid (BAL(f)) was investigated. Clinical respiratory isolates were added to BAL(f) suspensions containing lidocaine and to normal saline. The growth of two of four isolates of Streptococcus pneumoniae was significantly reduced in the presence of lidocaine-BAL(f) compared with controls in saline. Growth of Moraxella catarrhalis isolates was reduced in normal saline when compared with BAL(f) containing lidocaine. There was no effect upon the growth of Haemophilus influenzae, Pseudomonas aeruginosa and Candida albicans isolates. The recovery of isolates of S. pneumoniae may be reduced below the critical threshold of 10(5) cfu/mL during bronchoscopy when using lidocaine as a local anaesthetic.

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