Photobactericidal activity of methylene blue derivatives against vancomycin-resistant Enterococcus spp. | Zendy

Mark Wainwright | Zendy; David A. Phoenix | Zendy; M. Gaskell | Zendy; Barry J. Marshall | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Photobactericidal activity of methylene blue derivatives against vancomycin-resistant Enterococcus spp.

Author(s) -

Mark Wainwright,

David A. Phoenix,

M. Gaskell,

Barry J. Marshall

Publication year - 1999

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/44.6.823

Subject(s) - methylene blue , enterococcus , microbiology and biotechnology , vancomycin , chemistry , methylene , vancomycin resistant enterococcus , enterococcus faecalis , bacteria , biology , antibiotics , escherichia coli , staphylococcus aureus , biochemistry , organic chemistry , genetics , photocatalysis , gene , catalysis

The toxicities and phototoxicities of methylene blue and its two methylated derivatives were measured against one standard and three vancomycin-resistant pathogenic strains of Enterococcus spp. Each of the compounds was bactericidal and the derivatives exhibited photobactericidal activity on illumination at a 'light' dose of 6.3 J/cm(2) against one or more of the strains. Increased bactericidal and photobactericidal activity in the methylated derivatives is thought to be due to their higher hydrophobicities allowing greater interaction with the bacterial cell wall. In addition, the derivatives exhibited higher inherent photosensitizing efficacies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research