Cytopathic effect inhibition assay for determining the in-vitro susceptibility of herpes simplex virus to antiviral agents | Zendy

Manuel Cotarelo | Zendy; Pilar Catalán | Zendy; Carlos SánchezCarrillo | Zendy; Ana Ruiz | Zendy; Emilia Cercenado | Zendy; Antônio Tenório | Zendy; Emilio Bouza | Zendy

Open Access

Cytopathic effect inhibition assay for determining the in-vitro susceptibility of herpes simplex virus to antiviral agents

Author(s) -

Manuel Cotarelo,

Pilar Catalán,

Carlos SánchezCarrillo,

Ana Ruiz,

Emilia Cercenado,

Antônio Tenório,

Emilio Bouza

Publication year - 1999

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/44.5.705

Subject(s) - cytopathic effect , herpes simplex virus , virology , in vitro , virus , biology , microbiology and biotechnology , genetics

We compare a rapid dilution method for the determination of antiviral susceptibility of herpes simplex virus (HSV) with the plaque reduction assay. A total of 84 HSV clinical isolates were studied by both methods to detect in-vitro resistance to acyclovir and foscarnet. The rapid method showed for the detection of HSV isolates resistant to acyclovir and foscarnet, a sensitivity of 96. 8% and 100% and specificity of 100% and 100%, respectively. This method provides an easy and accurate screening procedure for the susceptibility testing of HSV to antiviral agents.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research