Intracerebral activity of antibiotics against Listeria monocytogenes during experimental rhombencephalitis | Zendy

Stéphane Blanot | Zendy; Claire Boumaila | Zendy; Patrick Berche | Zendy

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Intracerebral activity of antibiotics against Listeria monocytogenes during experimental rhombencephalitis

Author(s) -

Stéphane Blanot,

Claire Boumaila,

Patrick Berche

Publication year - 1999

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/44.4.565

Subject(s) - antibiotics , gentamicin , rifampicin , microbiology and biotechnology , ciprofloxacin , imipenem , vancomycin , listeria monocytogenes , bacteria , antibacterial agent , medicine , biology , staphylococcus aureus , antibiotic resistance , genetics

We used a model of rhombencephalitis in gerbils to test the efficacy of various antibiotics against Listeria monocytogenes. Gerbils were inoculated in the middle ear with strain EGD and treated subcutaneously with various antibiotics alone or in combination. We found that the most active antibiotics on intracerebral bacteria were amoxycillin, co-trimoxazole, rifampicin and imipenem. Vancomycin, gentamicin and ciprofloxacin were weakly or not active. The combinations amoxycillin-co-trimoxazole, amoxycillin-gentamicin and co-trimoxazole-rifampicin were highly active against intracerebral bacteria.

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