Ability of azlocillin and tobramycin in combination to delay or prevent resistance development in Pseudomonas aeruginosa | Zendy

Ya Li Wu | Zendy; Eileen Scott | Zendy; A. Li Wan Po | Zendy; Vicki Tariq | Zendy

Open Access

Ability of azlocillin and tobramycin in combination to delay or prevent resistance development in Pseudomonas aeruginosa

Author(s) -

Ya Li Wu,

Eileen Scott,

A. Li Wan Po,

Vicki Tariq

Publication year - 1999

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/44.3.389

Subject(s) - azlocillin , tobramycin , pseudomonas aeruginosa , microbiology and biotechnology , subculture (biology) , antibiotics , pseudomonas , cystic fibrosis , biology , medicine , bacteria , gentamicin , piperacillin , genetics

The ability of combinations of azlocillin and tobramycin to prevent or delay resistance development in eight Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients was studied using chequerboard titration and in-vitro serial subculture. No isolate had developed resistance to tobramycin after 12 treatments with the antibiotic combination. Azlocillin resistance had not developed in four isolates after 16 exposures, and was delayed in the other four isolates for at least eight exposures. Beta-lactamase production was responsible for azlocillin resistance in two isolates and occurred to a lesser extent in a third.

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