The effect of human lactoferrin on the MICs of doxycycline and rifampicin for Burkholderia cepacia and Pseudomonas aeruginosa strains | Zendy

Mustafa A. Alkawash | Zendy; Martha S. Head | Zendy; Issam Alshami | Zendy; James S. Soothill | Zendy

Open Access

The effect of human lactoferrin on the MICs of doxycycline and rifampicin for Burkholderia cepacia and Pseudomonas aeruginosa strains

Author(s) -

Mustafa A. Alkawash,

Martha S. Head,

Issam Alshami,

James S. Soothill

Publication year - 1999

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/44.3.385

Subject(s) - microbiology and biotechnology , burkholderia , pseudomonas aeruginosa , lactoferrin , cystic fibrosis , rifampicin , biology , sputum , doxycycline , pseudomonas , antibacterial agent , antibiotics , bacteria , medicine , tuberculosis , genetics , pathology

The presence of lactoferrin at the concentration found in cystic fibrosis (CF) sputum (0.9 g/L) reduced MICs and MBCs of doxycycline for Burkholderia cepacia and Pseudomonas aeruginosa strains. MICs for B. cepacia fell by 32- to 64-fold, from highly resistant to clinically achievable values. Rifampicin MICs for B. cepacia strains were reduced by lactoferrin and for some strains MBCs were reduced. These findings suggest new therapeutic approaches to infections and question the relevance of standard sensitivity tests for CF pathogens. Addition of lactoferrin to media for the routine sensitivity testing of CF isolates might give more relevant results.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research