Effects of voriconazole on Candida glabratain vitro | Zendy

Anjni Koul | Zendy; John C. Vitullo | Zendy; Guadalupe Reyes | Zendy; Mahmoud A. Ghannoum | Zendy

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Effects of voriconazole on Candida glabratain vitro

Author(s) -

Anjni Koul,

John C. Vitullo,

Guadalupe Reyes,

Mahmoud A. Ghannoum

Publication year - 1999

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/44.1.109

Subject(s) - voriconazole , candida glabrata , microbiology and biotechnology , fluconazole , ergosterol , in vitro , chemistry , candida albicans , biology , pharmacology , biochemistry , antifungal

The effects of voriconazole on the growth, morphology and lipids of Candida glabrata were studied. MIC data showed that voriconazole was up to 32- to 64-fold more active than fluconazole in its ability to inhibit various C. glabrata strains. Voriconazole inhibited the growth of C. glabrata in a dose-dependent fashion. Electron microscope examination showed that voriconazole treatment affected the external and internal morphology of C. glabrata. Treatment of C. glabrata with voriconazole inhibited ergosterol synthesis and led to accumulation of methylated sterols. In contrast, no significant difference in phospholipid composition was observed between treated and untreated cells.

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