Reduced glutaraldehyde susceptibility in Mycobacterium chelonae associated with altered cell wall polysaccharides | Zendy

Susan Manzoor | Zendy; Peter A. Lambert | Zendy; P.A. Griffiths | Zendy; M. John Gill | Zendy; A.P. Fraise | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Reduced glutaraldehyde susceptibility in Mycobacterium chelonae associated with altered cell wall polysaccharides

Author(s) -

Susan Manzoor,

Peter A. Lambert,

P.A. Griffiths,

M. John Gill,

A.P. Fraise

Publication year - 1999

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/43.6.759

Subject(s) - glutaraldehyde , microbiology and biotechnology , cell wall , isoniazid , mycobacterium chelonae , strain (injury) , mycobacterium , mycobacterium marinum , mutant , chemistry , biology , bacteria , biochemistry , chromatography , medicine , gene , tuberculosis , genetics , anatomy , pathology

Glutaraldehyde-resistant Mycobacterium chelonae have been isolated from endoscope washer disinfectors and endoscope rinse water. The mechanism of glutaraldehyde resistance is not well understood. Two spontaneous, glutaraldehyde-resistant mutants of the sensitive type strain, NCTC 946, were investigated. The colony morphology of the two mutants differed from that of the the type strain: colonies of the former were dry and waxy whereas those of the latter were smooth and shiny. Increased resistance to glutaraldehyde of the mutants was matched by small increases in the MICs of rifampicin and ethambutol but not isoniazid. Both mutants showed increased surface hydrophobicity. No changes were identified in the extractable fatty acids or the mycolic acid components of the cell wall but a reduction in each of the resistant strains in the arabinogalactan/arabinomannan portion of the cell wall was detected.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research