In-vitro antimicrobial activity of a carbapenem, MK-0826 (L-749,345) and provisional interpretive criteria for disc tests | Zendy

Peter Fuchs | Zendy

Open Access

In-vitro antimicrobial activity of a carbapenem, MK-0826 (L-749,345) and provisional interpretive criteria for disc tests

Author(s) -

Peter Fuchs

Publication year - 1999

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/43.5.703

Subject(s) - broth microdilution , imipenem , carbapenem , pseudomonas aeruginosa , microbiology and biotechnology , antimicrobial , in vitro , gram , enterobacteriaceae , minimum inhibitory concentration , biology , medicine , antibiotics , bacteria , antibiotic resistance , escherichia coli , biochemistry , genetics , gene

The in-vitro activity of MK-0826, a new oral carbapenem, was compared with that of imipenem by broth microdilution susceptibility tests against 545 bacterial isolates. MK-0826 had significantly greater activity against Enterobacteriaceae and poorer activity against Pseudomonas aeruginosa and many gram-positive species. MK-0826 disc diffusion tests were also performed according to the NCCLS procedure and tentative interpretive criteria were determined for possible susceptible MIC breakpoints of < or = 4.0 and < or = 2.0 mg/L.

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