Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum | Zendy

Manuel CuencaEstrella | Zendy; Beatriz RuizDíez | Zendy; Joaquı́n V. Martı́nez-Suárez | Zendy; Araceli Monzón | Zendy; Juan L. Rodrı́guez-Tudela | Zendy

Open Access

Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum

Author(s) -

Manuel CuencaEstrella,

Beatriz RuizDíez,

Joaquı́n V. Martı́nez-Suárez,

Araceli Monzón,

Juan L. Rodrı́guez-Tudela

Publication year - 1999

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/43.1.149

Subject(s) - scedosporium apiospermum , voriconazole , miconazole , flucytosine , itraconazole , ketoconazole , fluconazole , amphotericin b , microbiology and biotechnology , caspofungin , terbinafine , biology , antifungal

We report the in-vitro susceptibility of 27 clinical isolates of Scedosporium apiospermum and 43 of Scedosporium prolificans. S. apiospermum was resistant to fluconazole and flucytosine, with variable susceptibility to amphotericin B, itraconazole, ketoconazole and susceptible to miconazole. Voriconazole was much more active than fluconazole and flucytosine, more active than amphotericin B, itraconazole and ketoconazole and was as active as miconazole against S. apiospermum isolates. Voriconazole and the other six antifungal agents showed low activity against S. prolificans isolates.

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