Killing kinetics of intracellular Afipia felis treated with amikacin | Zendy

H. Le Pocher | Zendy; Philippe Brouqui | Zendy; Didier Raoult | Zendy

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Killing kinetics of intracellular Afipia felis treated with amikacin

Author(s) -

H. Le Pocher,

Philippe Brouqui,

Didier Raoult

Publication year - 1998

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/42.6.825

Subject(s) - amikacin , intracellular , felis , microbiology and biotechnology , biology , intracellular parasite , bacteria , antibiotics , virology , biochemistry , medicine , cats , genetics

Afipia felis is a facultative intracellular bacterium which multiplies in macrophages following inhibition of phagosome-lysosome (P-L) fusion. When A. felis-infected cells are incubated for 72 h with various antibiotics, only aminoglycosides are found to be bactericidal. We therefore studied the killing of intracellular A. felis by amikacin, and its relationship with the restoration of P-L fusion. Amikacin reduced the number of A. felis from 8.5 x 10(5) to 3.5 x 102 cfu/mL within 94 h. P-L fusion was restored after 30-40 h of incubation with amikacin. Both mechanisms may participate in the intracellular killing of bacteria.

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