Antimicrobial activity of the semisynthetic compound, hexahydrocolupulone | Zendy

Thomas Stephan | Zendy; E O Ngo | Zendy; Patricia Ferrieri | Zendy; John M. Besser | Zendy; Louise M. Nutter | Zendy

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Antimicrobial activity of the semisynthetic compound, hexahydrocolupulone

Author(s) -

Thomas Stephan,

E O Ngo,

Patricia Ferrieri,

John M. Besser,

Louise M. Nutter

Publication year - 1998

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/42.4.519

Subject(s) - microbiology and biotechnology , enterococcus faecium , staphylococcus aureus , bacillus subtilis , antimicrobial , mycobacterium tuberculosis , escherichia coli , vancomycin , biology , enterococcus , chemistry , antibiotics , bacteria , tuberculosis , medicine , biochemistry , genetics , pathology , gene

In this study we demonstrate that hexahydrocolupulone (HHC) more effectively inhibits the growth in vitro of Gram-positive organisms than Mycobacterium tuberculosis or Escherichia coli. Vancomycin-resistant Enterococcus faecium, methicillin-resistant Staphylococcus aureus, and coagulase-negative staphylococci were inhibited by HHC at concentrations < or = 4.06 mg/L. Growth inhibition profiles varied according to the microorganism evaluated (static for S. aureus and bactericidal for Bacillus subtilis).

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