Sub-MICs of sanfetrinem promote the interaction of human polymorphonuclear granulocytes with a multiply resistant strain of Klebsiella pneumoniae | Zendy

Annamaria Cuffini | Zendy; Viviana Cristina Tullio | Zendy; Angela Ianni Palarchio | Zendy; A Bonino | Zendy; Nicola Carlone | Zendy

Open Access

Sub-MICs of sanfetrinem promote the interaction of human polymorphonuclear granulocytes with a multiply resistant strain of Klebsiella pneumoniae

Author(s) -

Annamaria Cuffini,

Viviana Cristina Tullio,

Angela Ianni Palarchio,

A Bonino,

Nicola Carlone

Publication year - 1998

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/42.2.249

Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , phagocytosis , antibiotics , in vitro , bacteria , granulocyte , intracellular , biology , klebsiella , neutrophile , strain (injury) , enterobacteriaceae , antibacterial agent , immunology , escherichia coli , biochemistry , gene , genetics , anatomy

The effect of sanfetrinem, a member of a new class of antibiotics, upon the in-vitro interaction between human polymorphonuclear granulocytes (PMNs) and a multiply resistant strain of Klebsiella pneumoniae was investigated. Sub-MICs of sanfetrinem significantly enhanced PMN phagocytosis and greatly reduced the survival of intracellular bacteria compared with antibiotic-free systems. The distinction between any effect of sanfetrinem on the klebsiellae and the phagocytes was made by exposing each of them to the drug before they were incubated together. The results indicate that sanfetrinem may have a direct positive action either on K. pneumoniae or on human granulocytes.

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