Open AccessAntimicrobial susceptibility of community-acquired lower respiratory tract bacterial pathogens isolated in the UK during the 1995-1996 cold season
Author(s) -
D. Felmingham,
M J Robbins,
Y. Tesfaslasie,
Ian Harding,
S. B. Shrimpton,
R. N. Grüneberg
Publication year - 1998
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/41.3.411
Subject(s) - moraxella catarrhalis , microbiology and biotechnology , streptococcus pneumoniae , haemophilus influenzae , cefaclor , ciprofloxacin , moraxella (branhamella) catarrhalis , amoxicillin , penicillin , antimicrobial , clarithromycin , antibacterial agent , minimum inhibitory concentration , antibiotics , biology , cephalosporin
The antimicrobial susceptibility of 1078 isolates of Haemophilus influenzae, 348 Streptococcus pneumoniae and 258 Moraxella catarrhalis was determined. Overall 15.1% of H. influenzae produced beta-lactamase; 98.8% were susceptible to co-amoxiclav, 85.8% to cefaclor, 96% to clarithromycin and 100% to ciprofloxacin. The majority (94.2%) of M. catarrhalis produced beta-lactamase. The overall prevalence of low-level penicillin resistance (MIC = 0.12-1 mg/L) amongst isolates of S. pneumoniae was 3.4% and that of high-level resistance (MIC > or = 2 mg/L) was 3.7%. Most (96.3%) of the isolates of S. pneumoniae were susceptible to amoxycillin (MIC < or = 0.5 mg/L), 96% to cefaclor (MIC < or = 8 mg/L), 90.7% to clarithromycin (MIC < or = 0.25 mg/L) and 89% to ciprofloxacin (MIC < or = 1 mg/L).
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