Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model | Zendy

Martin A. Shapiro | Zendy; J. C. Sesnie | Zendy; T. M. Desaty | Zendy; Timothy J. Griffin | Zendy; Carl L. Heifetz | Zendy

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Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model

Author(s) -

Martin A. Shapiro,

J. C. Sesnie,

T. M. Desaty,

Timothy J. Griffin,

Carl L. Heifetz

Publication year - 1998

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/41.3.403

Subject(s) - pseudomonas aeruginosa , medicine , regimen , antibiotics , microbiology and biotechnology , pharmacology , surgery , biology , bacteria , genetics

A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with that of clinically relevant standard drugs. Following 50 mg/kg oral doses, twice daily for five consecutive days, clinafloxacin produced a 4 log decrease in mean bacterial count, the greatest decrease of all drugs tested. The same dosage regimen resulted in complete bacterial eradication in 88% of the kidneys. No other compound produced total bacterial clearance in 50% of the kidneys at the highest dose tested.

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