Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B against Cryptococcus neoformans | Zendy

Michael E. Klepser | Zendy; Erika J. Wolfe | Zendy; Michael A. Pfaller | Zendy

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Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B against Cryptococcus neoformans

Author(s) -

Michael E. Klepser,

Erika J. Wolfe,

Michael A. Pfaller

Publication year - 1998

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/41.3.397

Subject(s) - fluconazole , amphotericin b , cryptococcus neoformans , microbiology and biotechnology , pharmacodynamics , cryptococcosis , fungicide , cryptococcus , mycosis , antifungal , antifungal drug , biology , pharmacokinetics , pharmacology , immunology , botany

The activity of fluconazole and amphotericin B against three isolates of Cryptococcus neoformans was evaluated, with fluconazole and amphotericin B MICs of 2.0-4.0 mg/L and 1.0 mg/L respectively, using time-kill curve methods. Fluconazole was fungistatic against all isolates tested (<99.9% decrease in cfu from initial inoculum). The fungistatic activity of fluconazole was not enhanced by increasing the concentration of antifungal in solution. In contrast, amphotericin B was markedly fungicidal (> or = 99.9% decrease in cfu from initial inoculum). Both the rate and the extent of amphotericin B activity were enhanced when drug concentration was increased.

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