Sensitization of Burkholderia cepacia to antibiotics by cationic drugs | Zendy

Jayshree Rajyaguru | Zendy

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Sensitization of Burkholderia cepacia to antibiotics by cationic drugs

Author(s) -

Jayshree Rajyaguru

Publication year - 1998

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/41.2.277

Subject(s) - ceftazidime , antibiotics , theophylline , theobromine , medicine , colistin , enoxacin , burkholderia , pharmacology , microbiology and biotechnology , ofloxacin , ciprofloxacin , biology , pseudomonas aeruginosa , bacteria , genetics

Chlorpromazine and prochlorperazine have previously been shown to enhance the susceptibility of Burkholderia cepacia to aminoglycosides. To screen other non-antibiotic drugs containing similar amine (-N-CH3) groups, we examined a range of such agents that are in current clinical use for the treatment of non-infectious diseases, in combination with antibiotics that are ineffective against B. cepacia. At a concentration of 0.2 mM, theobromine, theophylline, trifluoperazine, fluophenazine and coumarin-152 significantly reduced (by four-fold) the MICs of gentamicin and ceftazidime. Theobromine and theophylline also reduced the MICs of amikacin and azithromycin.

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