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A plasmid-mediated beta-lactamase conferring resistance to cefotaxime in a Salmonella typhimurium clone found in St Petersburg, Russia
Author(s) -
Maria Gazouli,
Sidorenko Sv,
Εva Tzelepi,
Н. С. Козлова,
D. P. Gladin,
L. S. Tzouvelekis
Publication year - 1998
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/41.1.119
Subject(s) - cefotaxime , plasmid , clone (java method) , microbiology and biotechnology , biology , salmonella , beta lactamase , enterobacteriaceae , virology , escherichia coli , bacteria , genetics , antibiotics , gene
Four clinical and two environmental isolates of cefotaxime-resistant Salmonella typhimurium strains collected in St Petersburg, Russia, were studied. Molecular typing demonstrated that they constituted a single clone. The isolates expressed a cefotaxime-hydrolysing beta-lactamase with a pl of 8.4. The enzyme was encoded by a 12 kb plasmid which did not hybridize with TEM, SHV or ampC probes.

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