The effect of a combination of Iso-Sensitest agar and ampicillin on the detection of enterobacter beta-lactamase | Zendy

M Österblad | Zendy; Pentti Huovinen | Zendy

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The effect of a combination of Iso-Sensitest agar and ampicillin on the detection of enterobacter beta-lactamase

Author(s) -

M Österblad,

Pentti Huovinen

Publication year - 1998

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/41.1.107

Subject(s) - ampicillin , enterobacter cloacae , agar , macconkey agar , microbiology and biotechnology , enterobacter , beta lactamase , amp resistance , antibiotics , biology , enterobacteriaceae , bacteria , escherichia coli , biochemistry , genetics , gene

The ampicillin MICs for faecal strains of E. cloacae (n = 11) and Enterobacter species not identified to species level (n = 3) were noticed to be two-fold to four-fold lower on Iso-Sensitest than on Mueller-Hinton II agar. The levels of inducible beta-lactamase on Iso-Sensitest, Mueller-Hinton, and a selective MacConkey-based agar, with and without ampicillin, were determined. The level produced on Iso-Sensitest with ampicillin was comparable to that induced by Mueller-Hinton alone. We conclude that when routine procedures for the detection of beta-lactamase-based resistance are evaluated, not only should care be taken to choose the right antibiotics, but also different combinations of beta-lactams and agar should be tested.

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