Open AccessIn-vitro susceptibility of Helicobacter pylori to ampicillin, clarithromycin, metronidazole and omeprazole
Author(s) -
Vivian G. Loo,
Carlo A Fallone,
Eduardo de Souza,
Jocelyne Lavallée,
Alan Barkun
Publication year - 1997
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/40.6.881
Subject(s) - omeprazole , clarithromycin , helicobacter pylori , ampicillin , metronidazole , agar dilution , agar dilution method , microbiology and biotechnology , minimum inhibitory concentration , antibacterial agent , antimicrobial , population , agar , medicine , antibiotics , chemistry , biology , bacteria , pharmacology , genetics , environmental health
The in-vitro activities of omeprazole and three antimicrobial agents against 89 clinical isolates of Helicobacter pylori from a population with duodenal ulcer disease were determined by an agar dilution method. Resistance rates were 20% for metronidazole (MIC > 8 mg/L), 1% for clarithromycin (MIC > 2 mg/L) and zero for ampicillin (MIC > 8 mg/L). Omeprazole was relatively active against H. pylori in vitro (MIC < or = 8 mg/L).