Therapy of deep fungal infection in haematological malignancy. Working Party of the British Society for Antimicrobial Chemotherapy | Zendy

A. G. Prentice | Zendy; Rosemary A. Barnes | Zendy; Thomas R. Rogers | Zendy; J. Cohen | Zendy; David W. Denning | Zendy; E. G. V. Evans | Zendy; R. J. Hay | Zendy; D. C. E. Speller | Zendy; David W. Warnock | Zendy; Richard Warren | Zendy

Open Access

Therapy of deep fungal infection in haematological malignancy. Working Party of the British Society for Antimicrobial Chemotherapy

Author(s) -

A. G. Prentice,

Rosemary A. Barnes,

Thomas R. Rogers,

J. Cohen,

David W. Denning,

E. G. V. Evans,

R. J. Hay,

D. C. E. Speller,

David W. Warnock,

Richard Warren

Publication year - 1997

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/40.6.779

Subject(s) - amphotericin b , fluconazole , antimicrobial , malignancy , chemotherapy , antibiotics , drug resistance , intensive care medicine , medicine , drug , limiting , antifungal , biology , pharmacology , microbiology and biotechnology , mechanical engineering , engineering

The treatment of deep fungal infection in haematological malignancy remains controversial due to the limited number of antifungal agents available and problems over their spectrum and dose-limiting side-effects. Difficulties in diagnosis mean that most treatments are begun empirically; amphotericin B remains the drug of choice. Emerging resistance may limit the usefulness of fluconazole and other azoles in some areas. Lipid preparations of amphotericin B have reduced the toxicity of this agent, but some issues of dosage and efficacy remain. Adjunctive treatments aimed at augmenting the host response to infection may have a role to play in deep fungal infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research