Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance | Zendy

James Versalovic | Zendy

Open Access

Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance

Author(s) -

James Versalovic

Publication year - 1997

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/40.2.283

Subject(s) - 23s ribosomal rna , helicobacter pylori , clarithromycin , point mutation , microbiology and biotechnology , mutation , biology , drug resistance , gene , genetics , ribosome , rna

Fifty-four of 59 (91.5%) clarithromycin-resistant isolates of Helicobacter pylori from different patients possessed either the A2143G (formerly A2058G) or the A2144G (formerly A2059G) mutation in the gene encoding 23S rRNA. The A2143G mutation was significantly more likely to occur in isolates with MICs exceeding 64 mg/L (65% versus 30% with the A2144G mutation; P = 0.01). The majority (26 of 31; 83.9%) of isolates with the A2143G mutation had MICs exceeding 64 mg/L. Peptic ulcer disease recurred in a substantial proportion of patients infected with H. pylori strains containing either the A2143G or the A2144G mutation.

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