Effects of biocides on Acanthamoeba castellanii as measured by flow cytometry and plaque assay | Zendy

Watcharee Khunkitti | Zendy

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Effects of biocides on Acanthamoeba castellanii as measured by flow cytometry and plaque assay

Author(s) -

Watcharee Khunkitti

Publication year - 1997

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/40.2.227

Subject(s) - biocide , biguanide , chlorhexidine , microbiology and biotechnology , flow cytometry , acanthamoeba , chemistry , virus quantification , biology , medicine , immunology , dentistry , virus , organic chemistry , metformin , insulin

The lethal effects of various biocides, in particular two agents (chlorhexidine diacetate and polyhexamethylene biguanide) on cysts and trophozoites of Acanthamoeba castellanii have been measured by both plaque assay and flow cytometry (FCM). Minimum amoebicidal concentrations against trophozoites were generally the same by the two methods whereas minimum cysticidal concentrations were occasionally higher by FCM. Concentrations of biguanides required to produce an equal reduction in viability were also higher by FCM than by plaque assay.

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