Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis | Zendy

C. PérezGiraldo | Zendy

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Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis

Author(s) -

C. PérezGiraldo

Publication year - 1997

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/39.5.643

Subject(s) - biofilm , staphylococcus epidermidis , acetylcysteine , microbiology and biotechnology , chemistry , micrococcaceae , minimum inhibitory concentration , staphylococcus aureus , bacteria , antibacterial agent , biology , antimicrobial , biochemistry , antibiotics , antioxidant , genetics

The influence of various concentrations (0.003-8 mg/mL) of N-acetylcysteine on the formation of biofilms by 15 strains of Staphylococcus epidermidis has been studied. A dose-related decrease in biofilm formation was observed, except with the lowest concentrations. The 'slime' index relative to the control was 63%, 55%, 46%, 34%, 26% and 26% in the presence of 0.25, 0.5, 1, 2, 4, and 8 mg/mL of N-acetylcysteine, respectively. These data are statistically significant. The inhibitory effect of 2 mg/mL of N-acetylcysteine on slime formation was also verified by electron microscopy.

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