Meropenem-induced alteration of the susceptibility of Escherichia coli and Staphylococcus aureus to the bactericidal activity of human polymorphonuclear leucocytes | Zendy

Irene Herrera-Insua | Zendy; Pablo F. Pérez | Zendy; Pedro Martínez | Zendy; Marı́a Luisa Gómez-Lus | Zendy; José M. Prieto | Zendy

Open Access

Meropenem-induced alteration of the susceptibility of Escherichia coli and Staphylococcus aureus to the bactericidal activity of human polymorphonuclear leucocytes

Author(s) -

Irene Herrera-Insua,

Pablo F. Pérez,

Pedro Martínez,

Marı́a Luisa Gómez-Lus,

José M. Prieto

Publication year - 1997

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/39.2.223

Subject(s) - meropenem , staphylococcus aureus , microbiology and biotechnology , imipenem , escherichia coli , antibiotics , phagocytosis , antimicrobial , chemistry , bacteria , biology , antibiotic resistance , biochemistry , genetics , gene

The analysis of the interaction between antimicrobials and phagocytosis in vitro provides information additional to standard MIC and MBC estimations in predicting in-vivo efficacy. This study investigated the effects of meropenem, a newly available carbapenem, on the activities of human neutrophils against Escherichia coli and Staphylococcus aureus. The results were compared with those obtained with imipenem. Pretreatment of E. coli and S. aureus with meropenem and imipenem sensitized the bacteria to leucocytic killing. In the presence of antibiotics, opsonophagocytic killing of E. coli, but not S. aureus, was synergistically enhanced.

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