In-vitro killing activity of combinations of beta-lactam agents with aminoglycosides against penicillin-resistant pneumococci | Zendy

L. Schlegel | Zendy

Open Access

In-vitro killing activity of combinations of beta-lactam agents with aminoglycosides against penicillin-resistant pneumococci

Author(s) -

L. Schlegel

Publication year - 1997

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/39.1.95

Subject(s) - netilmicin , penicillin , cefotaxime , kanamycin , microbiology and biotechnology , streptococcus pneumoniae , antibiotics , imipenem , streptomycin , antibacterial agent , gentamicin , medicine , biology , antibiotic resistance , tobramycin

Streptococcus pneumoniae has developed resistance to almost every antibacterial agent used in clinical practice, including the most active beta-lactams. This has led to the proposed use of drug combinations. The aim of this study was to determine the efficacy of combinations of beta-lactam agents (cefotaxime or imipenem) with aminoglycosides (gentamicin, netilmicin or amikacin) against pneumococci showing high-level resistance to penicillin and streptomycin and/or kanamycin. All tested combinations were bactericidal and synergic despite the weak concentrations of antibiotics used. Our results suggest that combinations of beta-lactam agents with aminoglycosides may be useful for treating infections by penicillin-resistant pneumococci located outside the central nervous system.

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