The in-vitro anti-rickettsial activity of macrolides | Zendy

Avi Keysary | Zendy; Avi Itzhaki | Zendy; Ethan Rubinstein | Zendy; Ctaaya Oron | Zendy; Gershon Keren | Zendy

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The in-vitro anti-rickettsial activity of macrolides

Author(s) -

Avi Keysary,

Avi Itzhaki,

Ethan Rubinstein,

Ctaaya Oron,

Gershon Keren

Publication year - 1996

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/38.4.727

Subject(s) - rickettsia conorii , azithromycin , clarithromycin , rickettsia , microbiology and biotechnology , rickettsia typhi , spotted fever , in vitro , q fever , vero cell , boutonneuse fever , biology , coxiella burnetii , virology , rickettsiaceae , antibiotics , virus , biochemistry

The anti-rickettsial activity of azithromycin and clarithromycin was studied in Vero cells. The rate of rickettsial inhibition-growth caused by both macrolides was determined using rickettsial counts and ELISA. Both macrolides inhibited > 50% the growth of Rickettsia conorii and Rickettsia typhi at concentrations of 1.0 and 0.1 mg/L, respectively. The growth of Coxiella burnetii was inhibited to a rate of > or = 50% at the concentrations of 0.01 and 1.0 mg/L of azithromycin and clarithromycin, respectively.

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