Kill kinetics of antimicrobial agents against Helicobacter pylori | Zendy

Robert K. Flamm | Zendy; Jill Beyer | Zendy; Shinji Tanaka | Zendy; Jacob J. Clement | Zendy

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Kill kinetics of antimicrobial agents against Helicobacter pylori

Author(s) -

Robert K. Flamm,

Jill Beyer,

Shinji Tanaka,

Jacob J. Clement

Publication year - 1996

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/38.4.719

Subject(s) - clarithromycin , metronidazole , ciprofloxacin , antimicrobial , helicobacter pylori , microbiology and biotechnology , antibacterial agent , antibiotics , incubation , metabolite , amoxicillin , chemistry , biology , medicine , biochemistry

We evaluated the activity of clarithromycin, 14-OH clarithromycin, amoxycillin, bismuth, metronidazole and ciprofloxacin against six strains of Helicobacter pylori to determine if there were differences in response to these antimicrobial agents during growth in vitro. Clarithromycin and its 14-hydroxy-metabolite exhibited an early bactericidal activity with at least a 3 log10 reduction after 2-8 incubation. Exposure to bismuth, ciprofloxacin and metronidazole resulted in a > 3 log reduction by 24 h with the greatest decrease in viability occurring between 8 and 24 h. The viable count of three strains was reduced by a 1-2 log10 after 24 h exposure to amoxycillin and by a > 3 log10 after 48 h.

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