The quality of clinical serum teicoplanin assays: an experimental European EQA distribution | Zendy

L. O. White | Zendy; C. M. McMullin | Zendy; Adrienne Davis | Zendy; Alasdair MacGowan | Zendy; Ian Harding | Zendy; D. S. Reeves | Zendy

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The quality of clinical serum teicoplanin assays: an experimental European EQA distribution

Author(s) -

L. O. White,

C. M. McMullin,

Adrienne Davis,

Alasdair MacGowan,

Ian Harding,

D. S. Reeves

Publication year - 1996

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/38.4.701

Subject(s) - external quality assessment , teicoplanin , fluorescence polarization immunoassay , chromatography , high performance liquid chromatography , immunoassay , bioassay , medicine , chemistry , biology , bacteria , pathology , immunology , staphylococcus aureus , vancomycin , antibody , genetics

Two sets of six samples of human serum spiked with predetermined concentrations of teicoplanin were circulated, 6 months apart, to 22 European laboratories for the purposes of external quality assessment (EQA). The laboratories returned assay results using either bioassay, high-performance liquid chromatography (HPLC) or fluorescence polarization immunoassay (FPIA). FPIA was the most popular method and performance was generally satisfactory. Some laboratories using HPLC or microbiological assay performed satisfactorily but others did not. Only seven laboratories (32%) showed consistently satisfactory performance. There appears to be a need for continuing EQA of clinical teicoplanin assays.

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